Rat alpha 1-cysteine proteinase inhibitor. An acute phase reactant identical with alpha 1 acute phase globulin.

Acute-Phase Proteins: Alpha -1- Acid Glycoprotein

Acute-phase proteins are proteins whose plasma concentrations increase in response to inflammation. The variability in protein plasma levels, and following impact on drug binding extent, cause modifications in the mode of drug action, distribution, disposition and elimination. One of the most important acute phase proteins is a1-acid glycoprotein (AAG or AGP), principal binding protein for basi...

Alpha 1-proteinase inhibitor (human) shortage.

Alpha-1 protease inhibitor and antichymotrypsin levels in acute pancreatitis.

BACKGROUND Acute pancreatitis with high mortality of severe onset is still a major problem in medicine. Early identification of the severity of the disease is critical for effective treatment. Many markers have been tried and are still being tested. The ideal marker should be able to identify the cases and distinguish between mild and severe. METHODS This prospective study included 34 cases (...

Endothelin-1 in subarachnoid hemorrhage: An acute-phase reactant produced by cerebrospinal fluid leukocytes.

BACKGROUND AND PURPOSE The most potent vasoconstrictor known, endothelin-1, is currently considered to mediate cerebral vasospasm in subarachnoid hemorrhage (SAH), which can cause delayed cerebral ischemia. In our study, we performed clinical and in vitro experiments to investigate the origin and the mechanisms of the secretion of endothelin-1 in SAH. METHODS Endothelin-1 and markers of infla...

Chronic concern over an acute-phase reactant: a teachable moment.

A59-year-oldmanwith a history of shoulder and knee pain presented to our clinic reporting 6 years of left osteoarthritic hippain.Hispainhadbeenprogressive, and at the timeofpresentation,he required theuseofacane for support. The results of radiologic studies showed a loss of joint space with thinning of the upper aspect of the lefthip jointwithbone-on-boneappearanceandsubchondral cyst formation...